Cell Permeable Rho Inhibitor (C3 Trans based)) from Cytoskeleton, Inc.

Product Specs
ItemCell Permeable Rho Inhibitor (C3 Trans based))
CompanyCytoskeleton, Inc.
Price Pricing Info Supplier Page View Company Product Page
Catalog NumberCT04-B
Quantity5 x 20 µg
Brand/TrademarkCytoskeleton, Inc

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Cytoskeleton, Inc.

1830 S. Acoma St.

Denver, Colorado 80223

United States

Phone: 303 322-2254
303 322-2257

Company Profile

Website: http://cytoskeleton.com/

(1) Soluble TREM2 ameliorates tau phosphorylation and cognitive deficits through activating transgelin-2 in Alzheimer''s diseaseNature communicationsOctober 21, 2023Zhang X, Tang L, Yang J, Meng L, Chen J, Zhou L, Wang J, Xiong M, Zhang Z.1:1000), and p-tau T231 (381181, 1:1000) were from Zenbio. Cell-permeable Rho inhibitor (C3 Trans based) (CT04-A), RhoA activator (Cytoskeleton, CN01), and Rhotekin RBD protein on GST beads (RT02-A) were purchased

(2) Mechanosensitive accumulation of non-muscle myosin IIB during mitosis requires its translocation activityiScienceOctober 20, 2023Chao Wang, Jingjing Ding, Qiaodong Wei, Shoukang Du, Xiaobo Gong, Ting Gang Chewinhibitor: p-nitro-blebbistatin (Cayman Chemical, 24171); Rho inhibitor: C3 exoenzyme (Cytoskeleton, CT04); ROCK inhibitor: Y-27632 (MedChemExpress, HY-10583); CDK1 inhibitor: RO-3306 (Selleckchem, S7747).

(3) Key role for Rac in the early transcriptional response to extracellular matrix stiffness and stiffness-dependent repression of ATF3Journal of cell scienceOctober 1, 2023Dang I, Brazzo JA, Bae Y, Assoian RK.min at 37°C in 10% CO2 and 10 µM EHT1864 (3872, Tocris or 17258, Cayman Chemical) or 2 µg/ml CT04 (CT04-A, Cytoskeleton). Stock solutions of EHT1864 and CT04 were generated as per the manufacturers’ instructions.

(4) Microenvironmental mechanoactivation through Yap/Taz suppresses chondrogenic gene expressionMolecular Biology of the CellJune 1, 2023Grey F. Hallström, Dakota L. Jones, Ryan C. Locke, Edward D. Bonnevie, Sung Yeon Kim, Lorielle Laforest, Diana Cruz Garcia, Robert L. Mauckglass slide. Pharmacological regulation of RhoA activity To inhibit Rho activity, C3 (Cytoskeleton; CT04-A) was applied at 0.3 mg/ml while Rho activation was achieved via oleoyl-l-α-lysophosphatidic acid sodium

(5) In mitosis integrins reduce adhesion to extracellular matrix and strengthen adhesion to adjacent cellsNature CommunicationsApril 14, 2023Maximilian Huber, Javier Casares-Arias, Reinhard Fässler, Daniel J. Müller, Nico Strohmeyerthroughout the experiments. For inhibition of RhoA cells were incubated with 0.5 µg ml–1 Rho inhibitor I (# CT04, Cytoskeleton) in the culture flask for 4 h prior to their detachment. The inhibitor was present during

(6) Actin-regulated Siglec-1 nanoclustering influences HIV-1 capture and virus-containing compartment formation in dendritic cellseLifeMarch 20, 2023Enric Gutiérrez-Martínez, Susana Benet Garrabé, Nicolas Mateos, Itziar Erkiziac, Jon Ander Nieto-Garai, Maier Lorizate, Kyra J E Borgman, Carlo Manzo, Felix Campelo, Nuria Izquierdo-Useros, et al.Thermo Fisher. The SIR-Actin Spirochrome Kit (CY-SC001), the Rho Inhibitor I ADP ribosylation of Rho Asn-41 (CT04) and Rho Activator II (CN03) were obtained from Cytoskeleton. The phosphor-ezrin inhibitor NSC668394

(7) CLIC and membrane wound repair pathways enable pandemic norovirus entry and infectionNature communicationsFebruary 28, 2023Ayyar BV, Ettayebi K, Salmen W, Karandikar UC, Neill FH, Tenge VR, Crawford SE, Bieberich E, Prasad BVV, Atmar RL, et al.A,SCBT,sc-200861 Golgicide A,SCBT,sc-215103 EIPA,SCBT,sc-202458 ML141,SCBT,sc-362768 NSC 23766,SCBT,sc-204823 CT04,Cytoskeleton Inc.,CT04 CAS 879127-07-8,SCBT,sc-203934 Calphostin C,Sigma,C6303 Blebbistatin,SCBT,sc-203532B Wiskostatin,SCBT,sc-204399 Bafilomycin A1

(8) The mechanosensitive ion channel PIEZO1 promotes satellite cell function in muscle regenerationLife Science AllianceFebruary 1, 2023Kotaro Hirano, Masaki Tsuchiya, Akifumi Shiomi, Seiji Takabayashi, Miki Suzuki, Yudai Ishikawa, Yuya Kawano, Yutaka Takabayashi, Kaori Nishikawa, Kohjiro Nagao, et al.plating medium to analyse S-phase entry. Rho activator II (CN03; Cytoskeleton, Inc.) or Rho inhibitor I (CT04; Cytoskeleton, Inc.) was added to the plating medium at indicated time points shown in Figs 7F and I

(9) Cytokinesis machinery promotes cell dissociation from collectively migrating strands in confinementScience AdvancesJanuary 13, 2023Robert A. Law, Alexander Kiepas, Habben E. Desta, Emiliano Perez Ipiña, Maria Parlani, Se Jong Lee, Christopher L. Yankaskas, Runchen Zhao, Panagiotis Mistriotis, Nianchao Wang, et al.1 μM; I0634, Sigma-Aldrich), blebbistatin (50 μM; B0560, Sigma-Aldrich), Rho inhibitor I (1 μg/ml; CT04-A, Cytoskeleton Inc.), LPA (50 μM; L7260, Sigma-Aldrich), paclitaxel (taxol equivalent) (1 μM; P3456,

(10) Senescent stroma induces nuclear deformations in cancer cells via the inhibition of RhoA/ROCK/myosin II-based cytoskeletal tensionPNAS NexusJanuary 10, 2023Ivie Aifuwa, Byoung Choul Kim, Pratik Kamat, Bartholomew Starich, Anshika Agrawal, Derin Tanrioven, Teresa R Luperchio, Angela M Jimenez Valencia, Tania Perestrelo, Karen Reddy, et al.nonmuscle myosin II inhibitor Blebbistatin (Sigma), the ROCK inhibitor Y27632 (Sigma), the Rho inhibitor CT04 (Cytoskeleton Inc.), and the Rho activator CN03 (Cytoskeleton Inc.), the actin polymerization drug Jasplakinolide

(11) Mechanical stimulation promotes MSCs healing the lesion of intervertebral disc annulus fibrosusFrontiers in bioengineering and biotechnologyJanuary 1, 2023Deng R, Kang R, Jin X, Wang Z, Liu X, Wang Q, Xie L.stimulation was conducted for 1 h each day, and Cell Permeable RhoA Inhibitor C3 transferase based (CT04, Cytoskeleton, United States) was added. In the mechanical load group, cells differentiated with a mechanical

(12) Inhibition of β1-AR/Gαs signaling promotes cardiomyocyte proliferation in juvenile mice through activation of RhoA-YAP axiseLifeDecember 8, 2022Sakabe M, Thompson M, Chen N, Verba M, Hassan A, Lu R, Xin M.kit,Qiagen,74104, "chemical compound, drug",Epinephrine,Sigma,E4375,100 mM "chemical compound, drug",C3,Cytoskeleton,CT04,1 mg/ml "chemical compound, drug",GO4,Provided by Dr. Yi Zheng,,100 mM "chemical compound, drug",Tamoxifen,Sigma,T5648,"50

(13) YAP promotes cell-autonomous immune responses to tackle intracellular Staphylococcus aureus in vitroNat CommunNovember 16, 2022Robin Caire, Estelle Audoux, Mireille Thomas, Elisa Dalix, AurÃ©lien Peyron, Killian Rodriguez, Nicola Pordone, Johann Guillemot, Yann Dickerscheit, Hubert Marotte, et al.using the EPA technique described above. Additionally, cell permeable C3 exoenzyme from C. botulinum (CT04, Cytoskeleton, Denver, CO, USA) was used at 1 µg/mL, while CQ was used at 50 µM to treat cells. In HEK293 cells

(14) Differential dysregulation of granule subsets in WASH-deficient neutrophil leukocytes resulting in inflammationNature communicationsSeptember 21, 2022Johnson JL, Meneses-Salas E, Ramadass M, Monfregola J, Rahman F, Carvalho Gontijo R, Kiosses WB, Pestonjamasp K, Allen D, Zhang J, et al.were treated for 1 hour with a RhoA inhibitor (cell-permeable C3 Transferase, 2 µg/ml, Cytoskeleton, CT04), a Rac1 activator (CID888706, 10 µM), the Arp2/3 inhibitor CK666 (50 µM or 150 µM) or the Rab27a-JFC1 binding-inhibitor,

(15) YAP/TAZ activity in stromal cells prevents ageing by controlling cGAS-STINGNatureJuly 1, 2022Sladitschek-Martens HL, Guarnieri A, Brumana G, Zanconato F, Battilana G, Xiccato RL, Panciera T, Forcato M, Bicciato S, Guzzardo V, et al.2’,3’ dideoxycytidine (D5782) were from Sigma-Aldrich. Pyrintegrin (HY-13306) was from MedChemExpress. C3 (#CT04) was from Cytoskeleton Inc. Human smooth muscle cell growth medium 2 was from PromoCell (C-22062). The

(16) Active RhoA Exerts an Inhibitory Effect on the Homeostasis and Angiogenic Capacity of Human Endothelial CellsJournal of the American Heart AssociationJune 21, 2022Michael Hauke, Robert Eckenstaler, Anne Ripperger, Anna Ender, Heike Braun, Ralf A. Benndorfwas obtained from PeproTech (Rocky Hill, NJ). We bought the C3 transferase from Cytoskeleton (number CT04‐A; Denver, CO), the LIMK2 inhibitor LX7101 from Lexicon Pharmaceuticals (The Woodlands, TX), the LIMK1

(17) Interphase microtubule disassembly is a signaling cue that drives cell rounding at mitotic entryJournal of Cell BiologyJune 6, 2022Kévin Leguay, Barbara Decelle, Islam E. Elkholi, Michel Bouvier, Jean-François Côté, Sébastien CarrénoC3 transferase (Rho inhibitor I) and the Rho activator II (CN03) were purchased from Cytoskeleton (#CT04 and #CN03, respectively). Coelenterazine 400a was purchased from NanoLight Technology (#340). DNA and

(18) Substrate Stiffness-Driven Membrane Tension Modulates Vesicular Trafficking via Caveolin-1ACS nanoMarch 22, 2022Lachowski D, Matellan C, Gopal S, Cortes E, Robinson BK, Saiani A, Miller AF, Stevens MM, Del Río Hernández AE.polyacrylamide-coated fluorodishes 24 h prior to the experiment. Culture media-diluted 2.0 μg/mL Rho Inhibitor I (CT04-A, Cytoskeleton) or 5 μL/ml RhoA Activator I (CN01-A, Cytoskeleton) were added to the cells on the gels

(19) The Small GTPase RHOA Links SLP65 Activation to PTEN Function in Pre B Cells and Is Essential for the Generation and Survival of Normal and Malignant B CellsFrontiers in ImmunologyMarch 15, 2022Anila Vadakumchery et al.Cells were serum starved for 3 hours before treating with different concentrations of RHO Inhibitor (CT04, Cytoskeleton, Inc). After 16 hours cells were collected, washed and lysed with RIPA buffer containing

(20) The Short-Chain Fatty Acid Receptor GPR43 Modulates YAP/TAZ via RhoAMolecules and CellsJuly 31, 2021Bi-Oh Park, Seong Heon Kim, Jong Hwan Kim, Seon-Young Kim, Byoung Chul Park, Sang-Bae Han, Sung Goo Park, Jeong-Hoon Kim, Sunhong KimSystem Biosciences (USA), YM254890 from Adipogen (USA) and C3 toxin (C3 transferase from Clostridium botulinum , #CT04) from Cytoskeleton (USA). The GPR43-myc construct was cloned into PiggyBac cumate switch-inducible vector

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Cell Permeable Rho Inhibitor (C3 Trans based)) from Cytoskeleton, Inc.

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Cell Permeable Rho Inhibitor (C3 Trans based)) from Cytoskeleton, Inc.

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